This educational course is designed to provide an introductory overview of continuous kidney replacement therapy (CKRT), which is commonly used in the critical care setting. Several fundamental concepts will be addressed, including basics of kidney anatomy and function, options for kidney replacement in the critical care setting, fundamental principles governing different CKRT modalities, and a review of potential clinical challenges associated with CKRT. This is an opportunity for clinicians to enhance their familiarity with the terminology of CKRT and gain confidence in the understanding of its goals, mechanisms of action, and circuit components.