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Extracorporeal Membrane Oxygenation, otherwise known as ECMO, is a technique that provides respiratory and/or cardiac support to patients whose own heart and lungs are unable to meet the body’s metabolic demands. The use of this technique has increased dramatically over the past decade, with a wide range of potential clinical applications. This activity is designed to familiarize you with key physiologic principles of respiratory and cardiovascular functions, how common pathologic conditions can disrupt cardiopulmonary function, and the role of ECMO in helping to preserve cardiopulmonary function.