Fundamentals of Therapeutic Plasma Exchange (TPE)

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Therapeutic plasma exchange, or TPE, is a component of the management of a wide range of clinical conditions. TPE involves the separation and removal of plasma, which often contains pathologically relevant substances, from the other components of blood. This removed volume is accounted for with the infusion of a replacement solution that also has the potential to add individual components that may be absent or deficient in the patient. TPE may be provided with different techniques, and this course has been designed to educate providers on the core aspects of TPE procedures, common clinical indications for this therapeutic approach, potential complications of TPE, and other clinical considerations such as anticoagulation management.